Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor
نویسندگان
چکیده
منابع مشابه
The interferon antagonist ML protein of thogoto virus targets general transcription factor IIB.
The ML protein of Thogoto virus, a tick-transmitted orthomyxovirus, is a splice variant of the viral matrix protein and antagonizes the induction of antiviral type I interferon (IFN). Here we identified the general RNA polymerase II transcription factor IIB (TFIIB) as an ML-interacting protein. Overexpression of TFIIB neutralized the inhibitory effect of ML on IRF3-mediated promoter activation....
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2009
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.015172-0